Drug

Antimicrobials are cornerstones of infection treatment, but misuse and overuse are accelerating the global threat of antimicrobial resistance (AMR). At The Awosile Lab, we investigate how antimicrobials are used across human, animal, and environmental systems, and how resistance emerges from these practices. Our work blends surveillance, genomics, and One Health strategies with a commitment to stewardship and impact.

🔍 Our Areas of Focus

1. Patterns of Antimicrobial Use (AMU)

We study prescribing behaviors, over-the-counter access, and drug use in veterinary and human health, especially in low-resource settings to uncover misuse pathways and stewardship gaps.

2. Surveillance of Antimicrobial Resistance (AMR)

We track resistance gene presence particularly β‑lactamase genes in bacteria from clinical, agricultural, and environmental sources. This sheds light on transmission dynamics and stewardship needs.

3. Stewardship & Policy Advocacy

We support the design and evaluation of antimicrobial stewardship programs, local prescribing policies, and community engagement initiatives aimed at optimizing antimicrobial use.

4. Knowledge Translation

Research findings are translated into policy briefs, educational workshops, and direct engagement with healthcare and agricultural stakeholders to drive evidence-based, local interventions.

📚 Current & Recent Studies

• Beta‑lactamase resistance genes in Enterobacteriaceae from Nigeria
  A systematic review and meta‑analysis exploring ESBL, AmpC, and carbapenemase gene prevalence across humans, animals, and environments in Nigeria.

• Resistance to extended‑spectrum cephalosporins in E. coli and Salmonella enterica isolated from food-producing animals
  An ecological surveillance study comparing ESC resistance trends across national surveillance programs.

• Global antimicrobial resistance and use surveillance system (GLASS 2022)
  A multi-country analysis of antimicrobial consumption and resistance data.

✅ Why These Studies Matter

• Evidence-based stewardship: By linking resistance trends to drug use patterns, our research guides rational antimicrobial prescribing and policy design.

• One Health relevance: These studies cover resistance dynamics across human, veterinary, and environmental domains.

• Policy impact: Our findings contribute to national surveillance frameworks, risk assessments, and stewardship guidelines.